New York Yankees at Cleveland Indians odds, picks and best bets

The fifth-seeded New York Yankees and No. 4 seed Cleveland Indians continue their best-of-three Wild Card Series at Progressive Field Wednesday at 7:08 p.m. (on ESPN). Below, we analyze the Yankees-Indians MLB betting odds and lines, with picks and best bets.

Tuesday: New York took the opener 12-3, jumping on Cleveland ace Shane Bieber early as RF Aaron Judge hit a 2-run HR on the fourth pitch. It was one of four New York homers, while Gerrit Cole struck out 13 over seven innings in the win.

Yankees at Indians: Projected starting pitchers

RHP Masahiro Tanaka vs. RHP Carlos Carrasco

Tanaka went 3-3 with a 3.56 ERA (48 IP, 19 ER) in 10 starts this season.

• Last start: Loss, 4 IP, 3 ER, 8 H, 3 BB, 5 K at Toronto Blue Jays Sept. 23 - Yankees lost 14-1
• Career vs. Indians (regular season): 2-2, 4.00 ERA (36 IP, 16 ER) in 6 starts
• Career postseason: 5-3, 1.76 ERA (46 IP, 9 ER) in 8 starts

Carrasco went 3-4 with a 2.91 ERA (68 IP, 22 ER) in 12 starts.

• Last start: No-decision, 6 IP, 2 ER, 3 H, 3 BB, 8 K vs. Pittsburgh Pirates Friday - Indians won 4-3
• Career vs. Yankees (regular season): 5-5, 4.04 ERA (55 2/3 IP, 25 ER) in 12 starts
• Career postseason: 0-1, 1.64 ERA (11 IP, 2 ER) in 2 starts

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Yankees at Indians: Key injuries

(Get the latest injury news here.)

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Yankees at Indians: Odds, lines, picks and betting tips

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 2 p.m. ET.

Prediction

Indians 4, Yankees 2

Money line (ML)

The INDIANS (+ 115) are the STRONGEST PLAY, which should be 1.5 times your usual wager. They're not losing two in a row. It's that simple.

Tanaka and Carrasco faced off in a 2017 ALDS pitchers' duel in Game 3 at Yankee Stadium, tossing 7 and 5 2/3 scoreless innings, respectively. New York eventually won 1-0 thanks to a Greg Bird solo homer in the bottom of the seventh inning off Cleveland RP Andrew Miller.

Carrasco will get the best of Tanaka this time.

New to sports betting? Every winning $1 bet on the Indians ML will profit $1.15. Every $1.29 bet on the Yankees (-129) profits $1 if they prevail.

Run line/Against the spread (ATS)

Yankees -1.5 (+125) | Indians +1.5 (-150)

Since I'm backing the ML, I'm PASSING on the RL.

Over/Under (O/U)

Back the UNDER 8.5 ( -110) with a small-unit play, half your usual wager.

Both Tanaka and Carrasco haven't allowed more than 3 earned runs in each of their previous six starts. Tanaka boasts a 3.06 ERA in his last six games, while Carrasco is a robust 1.66 ERA in his last six.

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